abstract：:The prognostic significance of Bcl-2, Bcl-6, p53, topoisomerase II, and β-tubulin expression was evaluated in diffuse large B-cell lymphoma (DLBCL) patients treated with cyclophosphamide, doxorubicin, vincristine, prednisolone, and rituximab. Eight-year progression-free survival (PFS, P = 0.006) and overall survival (...

journal_title：International journal of hematology

authors： Choi YW,Ahn MS,Choi JH,Lee HW,Kang SY,Jeong SH,Park JS,Han JH,Kim JH,Sheen SS

更新日期：2016-02-01 00:00:00

abstract：:Multicenter, prospective study was conducted to evaluate the efficacy of biweekly romiplostim in maintaining platelet ≥ 30 × 10(9)/L for at least 4 weeks. Treatment was started with a weekly injection (1 mcg/kg), and the dose was escalated until a titrated dose was achieved that maintained a platelet 50-200 × 10(9)/L ...

journal_title：International journal of hematology

authors： Park S,Yoon SS,Lee JH,Park JS,Jang JH,Lee JW

更新日期：2016-01-01 00:00:00

abstract：:Hepcidin, the iron regulatory hormone, has three isoforms; -20, -22 and -25. While hepcidin-25 has been studied extensively, the physiological significance of other isoforms remains poorly understood. Using a quantitative method based on liquid chromatography-tandem mass spectrometry (LC-tandem MS) developed by our gr...

journal_title：International journal of hematology

authors： Addo L,Ikuta K,Tanaka H,Toki Y,Hatayama M,Yamamoto M,Ito S,Shindo M,Sasaki Y,Shimonaka Y,Fujiya M,Kohgo Y

更新日期：2016-01-01 00:00:00

abstract：:Internal tandem duplication in the FLT3 gene (FLT3/ITD), which is found in patients with acute myeloid leukemia (AML), causes resistance to FLT3 inhibitors. We found that RUNX1, a transcription factor that regulates normal hematopoiesis, is up-regulated in patients with FLT3/ITD(+) AML. While RUNX1 can function as a t...

journal_title：International journal of hematology

authors： Hirade T,Abe M,Onishi C,Taketani T,Yamaguchi S,Fukuda S

更新日期：2016-01-01 00:00:00

abstract：:We have previously shown the clinical usefulness of Wilms' tumor 1 gene (WT1) mRNA expression in peripheral blood (PB) as a minimal residual disease (MRD) monitoring marker in 191 acute myeloid leukemia (AML) patients using the WT1 mRNA assay kit "Otsuka" (Otsuka Pharmaceutical Co., Ltd.; "former kit"). In contrast, t...

journal_title：International journal of hematology

authors： Kitamura K,Nishiyama T,Ishiyama K,Miyawaki S,Miyazaki K,Suzuki K,Masaie H,Okada M,Ogawa H,Imai K,Kiyoi H,Naoe T,Yokoyama Y,Chiba S,Hata T,Miyazaki Y,Hatta Y,Takeuchi J,Nannya Y,Kurokawa M,Ueda Y,Koga D,Sugiyam

更新日期：2016-01-01 00:00:00

abstract：:Collection and analysis of information on diseases and post-transplant courses of allogeneic hematopoietic stem cell transplant recipients have played important roles in improving therapeutic outcomes in hematopoietic stem cell transplantation. Efficient, high-quality data collection systems are essential. The introdu...

journal_title：International journal of hematology

authors： Atsuta Y

更新日期：2016-01-01 00:00:00

abstract：:We retrospectively evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a reduced-intensity conditioning regimen consisting of fludarabine (125 mg/m²) and melphalan (140 mg/m²) for multiple myeloma. Twenty-three patients (median age: 46 years) were evaluated. Stem ...

journal_title：International journal of hematology

authors： Kikuchi T,Mori T,Koda Y,Kohashi S,Kato J,Toyama T,Nakazato T,Aisa Y,Shimizu T,Okamoto S

更新日期：2015-12-01 00:00:00

abstract：:A 55-year-old female with stage IVA follicular lymphoma in third complete remission underwent allogeneic peripheral blood stem cell transplantation. Neutrophil engraftment was achieved on day +18; however, platelet counts remained below 10 × 10(3)/µL, necessitating transfusions twice a week for more than 3 months. Bon...

journal_title：International journal of hematology

authors： Fujimi A,Kamihara Y,Hashimoto A,Kanisawa Y,Nakajima C,Hayasaka N,Yamada S,Okuda T,Minami S,Ono K,Iyama S,Kato J

更新日期：2015-10-01 00:00:00

abstract：:Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of...

journal_title：International journal of hematology

authors： Nomoto H,Takami A,Espinoza JL,Matsuo K,Mizuno S,Onizuka M,Kashiwase K,Morishima Y,Fukuda T,Kodera Y,Doki N,Miyamura K,Mori T,Nakao S,Ohtake S,Morishita E

更新日期：2015-10-01 00:00:00

abstract：:Extranodal natural killer/T cell lymphoma, nasal type (ENK/TCL), is an aggressive and rare hematological malignancy. Patients with advanced and relapsed/refractory disease have very poor outcomes. In this study, we retrospectively assessed the efficacy and safety of MEDA regimen (methotrexate, etoposide, dexamethasone...

journal_title：International journal of hematology

authors： Ding H,Chang J,Liu LG,Hu D,Zhang WH,Yan Y,Ma LY,Li ZC,Ma YJ,Hao SG,Tao R

更新日期：2015-08-01 00:00:00

abstract：:We report here the successful treatment of cold agglutinin-associated refractory hemolysis with bortezomib in a patient with Waldenström's macroglobulinemia (WM). A 78-year-old man was referred to our hospital with cold hemagglutinemia of unknown cause. Laboratory examination revealed a hemoglobin concentration of 6.9...

journal_title：International journal of hematology

authors： Izumi M,Tsunemine H,Suzuki Y,Tomita A,Kusumoto T,Kodaka T,Itoh K,Takahashi T

更新日期：2015-08-01 00:00:00

abstract：:Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by depositions of insoluble amyloid fibrils that are composed of fragments of monoclonal light chains produced by abnormal plasma cells. The prognosis is reported to be poor; median survival time (MST) is 1-2 years overall, and is 6 months in pa...

journal_title：International journal of hematology

authors： Ishiguro K,Hayashi T,Igarashi T,Maruyama Y,Ikeda H,Ishida T,Shinomura Y

更新日期：2015-08-01 00:00:00

abstract：:We report, for the first time, a non-syndromic infant with a reversible myeloproliferative disease that harbors a germline hereditary thrombopoietin (THPO) gene mutation, a condition that is known to induce familial thrombocytosis at increasing age. In order to investigate whether somatic THPO gene mutations play a ro...

journal_title：International journal of hematology

authors： Houwing ME,Koopman-Coenen EA,Kersseboom R,Gooskens S,Appel IM,Arentsen-Peters ST,de Vries AC,Reinhardt D,Stary J,Baruchel A,de Haas V,Blink M,Lopes Cardozo RH,Pieters R,Michel Zwaan C,van den Heuvel-Eibrink MM

更新日期：2015-07-01 00:00:00

abstract：:Osteonecrosis (ON) is a potentially disabling complication encountered in children who receive chemotherapy for acute lymphoblastic leukemia (ALL). Considering the possible effect of ethnic difference on the clinical features of symptomatic ON in pediatric ALL, we retrospectively evaluated 245 children with ALL who we...

journal_title：International journal of hematology

authors： Chen SH,Chang TY,Jaing TH,Lee MS,Wang CJ,Hung IJ,Yang CP

更新日期：2015-07-01 00:00:00

abstract：:We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to b...

journal_title：International journal of hematology

authors： Kojima M,Nakamura N,Yabe M,Tokunaka M,Kikuti YY,Kikuchi T,Murayama H,Moriuchi M,Tsuboi K,Ogawa Y,Ando K

更新日期：2015-05-01 00:00:00

abstract：:The clinical importance of the isolation of nontuberculous mycobacteria (NTM) from respiratory specimens of stem cell transplant (SCT) recipients is not clear. We investigated the characteristics and clinical impact of NTM isolation in this population. Medical records of adult patients who underwent SCT at the blood a...

journal_title：International journal of hematology

authors： Kang JY,Ha JH,Kang HS,Yoon HK,Kim HJ,Lee S,Lee DG,Jung JI,Kim SC,Kim YK

更新日期：2015-05-01 00:00:00

abstract：:Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and dendritic cells (DCs)] and their progenitors. Various studies have demonstrated that IRF8 is essential for the development of monocytes, DCs, eosinophils, ...

journal_title：International journal of hematology

authors： Tamura T,Kurotaki D,Koizumi S

更新日期：2015-04-01 00:00:00

abstract：:Granulocyte immunofluorescence and granulocyte agglutination tests are standard methods for detecting human neutrophil antigen (HNA) antibodies (Abs); however, these require a typed panel of neutrophils, which can be time-consuming to develop, and it remains difficult to determine antibody specificity in some cases. W...

journal_title：International journal of hematology

authors： Amakishi E,Irie Y,Nishizawa K,Kamada H,Nakajima F,Matsuyama N,Ishii H,Matsukura H,Yasui K,Hirayama F

更新日期：2015-04-01 00:00:00

abstract：:We analyzed the results of third allogeneic stem cell transplantation (SCT3) using single-unit unrelated cord blood (CB) in seven adult patients with relapsed acute leukemia after second allogeneic stem cell transplantation (SCT2). The median age at SCT 3 was 44 years (range 20-58 years). The patients had de novo acut...

journal_title：International journal of hematology

authors： Konuma T,Kato S,Ooi J,Ebihara Y,Mochizuki S,Oiwa-Monna M,Tojo A,Takahashi S

更新日期：2015-04-01 00:00:00

abstract：:According to the 2008 WHO classification, the category of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) includes atypical chronic myeloid leukaemia (aCML), chronic myelomonocytic leukaemia (CMML), MDS/MPN-unclassifiable (MDS/MPN-U), juvenile myelomonocytic leukaemia (JMML) and a "provisional" entity, refracto...

journal_title：International journal of hematology

authors： Zoi K,Cross NC

更新日期：2015-03-01 00:00:00

abstract：:This observational study aimed to assess real-world treatment patterns and clinical outcomes for patients with chronic immune thrombocytopenia (ITP) currently being treated with eltrombopag or romiplostim after switching from corticosteroids, rituximab, or the alternate thrombopoietin receptor agonist (TPO-RA). The st...

journal_title：International journal of hematology

authors： Kuter DJ,Macahilig C,Grotzinger KM,Poston SA,Wang PF,Dawson KL,Ward M

更新日期：2015-03-01 00:00:00

abstract：:Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. ...

journal_title：International journal of hematology

authors： Nakamura-Ishizu A,Suda T

更新日期：2014-10-01 00:00:00

abstract：:We propose an algorithm based on a slightly modified version of MD Anderson Cancer Center (MDACC) score (i.e., mutational status of IgVH, LDH, presence of high-risk FISH abnormalities), β2-microglobulin and separation of clinical monoclonal B-cell lymphocytosis (cMBL) from chronic lymphocytic leukemia (CLL) to predict...

journal_title：International journal of hematology

authors： Molica S,Giannarelli D,Levato L,Mirabelli R,Gentile M,Lentini M,Morabito F

更新日期：2014-09-01 00:00:00

abstract：:There is no standard treatment for adolescents aged 15 years or older with acute lymphoblastic leukemia (ALL), although this age group has been reported as having a poorer prognosis compared to younger patients. We retrospectively analyzed the outcomes of three consecutive Tokyo Children's Cancer Study Group ALL trial...

journal_title：International journal of hematology

authors： Kato M,Manabe A,Koh K,Inukai T,Kiyokawa N,Fukushima T,Goto H,Hasegawa D,Ogawa C,Koike K,Ota S,Noguchi Y,Kikuchi A,Tsuchida M,Ohara A

更新日期：2014-08-01 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a multipotent transcription factor that plays a pivotal role in immune reactions, inflammation, and possibly hematopoiesis as well. Mobilization of neutrophilic granulocytes during inflammation is a highly regulated process, but one that is incompletely understood. We studied the in v...

journal_title：International journal of hematology

authors： Knudsen E,Carlsen H,Bøyum A,Benestad HB,Iversen PO

更新日期：2014-08-01 00:00:00

abstract：:Gemcitabine is a nucleoside analogue used widely across haemato-oncology. Side effects are generally predictable, and typically consist of cytopenia, nausea, and infection. As the present case clearly demonstrates, gemcitabine is in rare cases associated with life-threatening large vessel vasculitis, which can involve...

journal_title：International journal of hematology

authors： Eyre TA,Gooding S,Patel I,Moore N,Hatton C,Collins GP

更新日期：2014-06-01 00:00:00

abstract：:Several clinical trials have demonstrated the effectiveness of bortezomib in combination with various anti-myeloma agents; however, no definitive information is available regarding drugs best suited for use in combination with bortezomib. Using isobologram analysis, we investigated the combined effects of bortezomib w...

journal_title：International journal of hematology

authors： Kikuchi J,Koyama D,Mukai HY,Furukawa Y

更新日期：2014-06-01 00:00:00

abstract：:Narrowband ultraviolet B phototherapy (NB-UVB) is a therapeutic alternative for haematopoietic stem cell transplantation-related skin graft-versus-host disease (GVHD). The beneficial effects of this intervention may be induced by direct irradiation of inflammatory cells in the skin; however, the putative involvement o...

journal_title：International journal of hematology

authors： Iyama S,Murase K,Sato T,Hashimoto A,Tatekoshi A,Horiguchi H,Kamihara Y,Ono K,Kikuchi S,Takada K,Kawano Y,Hayashi T,Miyanishi K,Sato Y,Takimoto R,Kobune M,Mori S,Kato J,Yamashita T,Kato J

更新日期：2014-04-01 00:00:00

abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterised by isolated thrombocytopenia (peripheral blood platelet count <100 × 10(9)/L) in the absence of other causes or disorders that may be associated with thrombocytopenia. The upfront treatment in newly diagnosed ITP patients is steroids; howeve...

journal_title：International journal of hematology

authors： Tripathi AK,Shukla A,Mishra S,Yadav YS,Yadav DK

更新日期：2014-04-01 00:00:00

abstract：:Increased levels of asparagine synthetase (ASNS), an enzyme producing intracellular asparagine, have been implicated in the development of asparaginase resistance. The aim of this study was to assess ASNS mRNA and protein expression in bone marrow cell populations of children with acute lymphoblastic leukemia (ALL). B...

journal_title：International journal of hematology

authors： Dimitriou H,Choulaki C,Perdikogianni C,Stiakaki E,Kalmanti M

更新日期：2014-03-01 00:00:00

abstract：:Anti-endothelial cell antibody (AECA) is well known to reflect endothelial injury. Graft-versus-host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), is also closely associated with endothelial injury. We hypothesized that AECA may be associated with GVHD. To inve...

journal_title：International journal of hematology

authors： Yao J,Song A,Cao W,Chen S,Zhou L,Cao S,Liu P,Wang M,Xu Y,Pang A,Feng S,Han M

更新日期：2014-03-01 00:00:00

abstract：:A 68-year-old female was diagnosed with acute myeloid leukemia (AML-M2 without 8/21 translocation) in December 2006. Although a complete remission (CR) was obtained after induction chemotherapy, the first post-remission therapy was discontinued because of severe cardiovascular complications. She had a relapse of AML w...

journal_title：International journal of hematology

authors： Tsunemine H,Akasaka H,Sakane EI,Ito K,Kodaka T,Takahashi T

更新日期：2014-02-01 00:00:00

abstract：:Despite the crucial aid that newly developed target therapies are providing to chemotherapy and stem cell transplant, the cure for many hematological malignancies is still an unmet need. Although available therapies are able to induce an effective debulking of the tumor, most of the time, an insidious minimal residual...

journal_title：International journal of hematology

authors： Bocchia M,Defina M,Aprile L,Sicuranza A

更新日期：2014-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20-24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers,...

journal_title：International journal of hematology

authors： Ikeda S,Tagawa H

更新日期：2014-01-01 00:00:00

abstract：:Lymphocytosis in response to dasatinib for chronic myelogenous leukemia (CML) may be associated with favorable response. However, it occurs at varying times and in a limited subset of patients. To identify early clinical markers for favorable responses applicable to all patients with or without lymphocytosis, we prosp...

journal_title：International journal of hematology

authors： Kumagai T,Matsuki E,Inokuchi K,Ohashi K,Shinagawa A,Takeuchi J,Yoshida C,Okamoto S,Wakita H,Kozai Y,Shirasugi Y,Fujisawa S,Iwase O,Yano S,Nishiwaki K,Oba K,Sakamoto J,Sakamaki H

更新日期：2014-01-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (alloSCT) is currently the only curative treatment modality for myelodysplastic syndromes (MDS). The treatment paradigm for MDS has changed in recent years with the introduction of hypomethylating agents (HMAs). The present retrospective multicenter study was designed...

journal_title：International journal of hematology

authors： Kim Y,Kim IH,Kim HJ,Park S,Lee KH,Kim SJ,Lee JH,Kim DY,Yoon SS,Kim YK,Jang JH,Park SY,Ahn JS,Cheong CW,Lee JH,Cheong JW,Korean Society of Hematology Acute myeloid Leukemia\/Myelodysplastic Syndrome Working Party.

更新日期：2014-01-01 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous neoplasm. Although several genetic and environmental factors have been postulated, no obvious risk factors have been emerged for DLBCL in the general population. DNA repair systems are responsible for maintaining the integrity of the genome and prote...

journal_title：International journal of hematology

authors： El-Din MA,Khorshied MM,El-Saadany ZA,El-Banna MA,Reda Khorshid OM

更新日期：2013-12-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive sp...

journal_title：International journal of hematology

authors： Krishnan SK,Hill A,Hillmen P,Arnold LM,Brooksbank GL,Wood A,Scarsbrook A,Davies MH,Kelly RJ

更新日期：2013-12-01 00:00:00

abstract：:Although anti-T lymphocyte globulin-Fresenius (ATG-F) is commonly used as prophylaxis for graft-versus-host disease (GVHD), the appropriate dosage of ATG-F in the setting of a reduced-intensity conditioning (RIC) regimen has not been determined. In the present study, we retrospectively analyzed the clinical outcomes o...

journal_title：International journal of hematology

authors： Fuji S,Ueno N,Hiramoto N,Asakura Y,Yakushijin K,Kamiyama Y,Kurosawa S,Kim SW,Heike Y,Yamashita T,Fukuda T

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast. CASE REPORT:We describe the case of a 39-year-old woman ...

journal_title：International journal of hematology

authors： Bouzguenda R,Khanfir A,Toumi N,Chaaben K,Hentati Y,Ayadi L,Feki W,Daoud J,Frikha M

更新日期：2013-10-01 00:00:00